Program
Day 1: Thursday, December 2, 2021
Welcome Remarks09:00-09:05
- Kazunori Oishi
- President, Toyama Institute of Health, Japan
Session 1:
Capsular Nomenclature09:05-09:50
- Chair:
- Shigetada Kawabata Osaka University Graduate School of Dentistry, Japan
SE1-1Capsule Expression among Oral Streptococci
- Moon H. Nahm
- University of Alabama at Birmingham, USA
SE1-2Two cases of bacteremia due to S. oralis expressing serotype 3 pneumococcal capsule
- Kei Kasahara
- Nara Medical University, Japan
Session 2:
Genetics and Genomics09:50-10:40
- Chair:
- Jun Kurushima Gumma University, Graduate School of Medicine, Japan
SE2-1Predication of β-lactam resistance phenotype
- Jie Feng
- Institute of Microbiology, Chinese Academy of Sciences, China
SE2-2 Exploring pneumococcal virulence factors via molecular evolutionary analysis
- Masaya Yamaguchi
- Osaka University Graduate School of Dentistry, Japan
Session 3:
Pneumococcus-host Interactions 10:50-11:50
- Chair:
- Soichiro Kimura Toho University of Medicine, Japan
SE3-1Survival strategy of S. pneumoniae by hijacking host autophagy
- Michinaga Ogawa
- National Institute of Infectious Diseases, Japan
SE3-2Capsule serotype-dependent evasion of resident macrophage capture
- Jing-Ren Zhang
- Tsinghua University, China
Luncheon Seminar 1:
Co-sponsored by MSD K.K.12:00-13:00
- Chair:
- Junichiro Nishi Kagoshima University Graduate School of Medicine and Dental Sciences, Japan
LS1-1Epidemiology of adult pneumococcal infections in Japan
- Koji Kuronuma
- Sapporo Medical University School of Medicine, Japan
LS1-2Current situation of pneumococcal disease in children in Japan
- Naruhiko Ishiwada
- Chiba University, Japan
Session 4:
Cost Effectiveness of Vaccine13:10-13:50
- Chair:
- Shin Sasaki Medical Affairs, MSD, Japan
SE4-1Economic evaluation of vaccines and vaccination programs:
Guides from global and Japanese experiences
- Manabu Akazawa
- Meiji Pharmaceutical University, Japan
SE4-2he Health Technology Assessment of pneumococcal vaccination in Japan:
Costeffectiveness and value assessment
- Ataru Igarashi
- Yokohama City University School of Medicine, Japan
Poster Session 14:00-16:00
Session 1: Clinical and Epidemiological research-1 14:00-14:35
- Chair:
- Naruhiko Ishiwada Chiba University, Japan
P-1 Current situation of pneumococcal disease in children in Japan Epidemiological change of invasive pneumococcal disease in children after the introduction of 13-valent pneumococcal conjugate vaccine in Japan
- Noriko Takeuchi
- Department of Infectious Diseases, Medical Mycology Research Center, Chiba, Japan
P-2 Pneumococcal Meningitis in Adults in 2014-2018 after Introduction of Pediatric 13-valent Pneumococcal Conjugate Vaccine in Japan
- Hiroyuki Fujikura
- National Institute of Infectious Diseases, Tokyo, Japan
P-3 Association of Serotype with Clinical Presentation of Invasive Pneumococcal Disease in Adults, Japan
- Kosuke Tamura
- Department of Research Planning, Toyama Institute of Health, Toyama, Japan
P-4 Changes in the notification rate of Invasive Pneumococcal Disease in Japan during the COVID-19 pandemic: Descriptive assessment of national surveillance data
- Reiko Shimbashi
- Surveillance Analysis Unit, Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan
P-5 Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in patients with hematological malignancies who were outside recommended ages for routine vaccination
- Kenichi Takeshita
- Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan
P-6 A Novel Real-time PCR Assay Targeting lytA, piaB, and SP2020 for Identification of Streptococcus pneumoniae
- Bhim Gopal Dhoubhadel
- Department of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
Poster Viewing and Discussion 14:35-15:00
Session 2: Clinical and Epidemiological research-2 15:00-15:35
- Chair:
- Kei KasaharaNara Medical University, Japan
P-7 Multiple Serotypes of Pneumococci in Patients With Pneumonia and Their Associated Risk Factors in Japan
- Bhim Gopal Dhoubhadel
- Department of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
P-8 Relationship between the Opacity Variance of Streptococcus pneumoniae Colonies and the Clinical Features of Adult Pneumococcal Pneumonia
- Kazuko Yamamoto
- Department of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan
P-9 Long-term impact of introduction of pneumococcal conjugate vaccines for children on adult pneumococcal pneumonia in Japan: Two multicenter observational studies from 2011 to 2020
- Haruka Maeda
- Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
P-10 Distribution and variation of serotypes and pneumococcal surface protein A clades of Streptococcus pneumoniae strains isolated from adult patients with invasive pneumococcal disease in Japan
- Bin Chang
- Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
P-11 Seroepidemiological Analysis of Anti-Pneumococcal Surface Protein A (PspA) Immunoglobulin G by Clades in Japanese Population
- Saeko Morino
- Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
P-12 Establishment of PspA-optimized OPA for human sera
- Yuka Koizumi
- The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan
Poster Viewing and Discussion 15:35-16:00
Session 3: Basic research-1 14:00-14:41
- Chair:
- Yuki KinjoThe Jikei University School of Medicine, Japan
P-13 Exposure to Cigarette Smoke Enhances Pneumococcal Transmission Among Littermates in an Infant Mouse Model
- Daichi Murakami
- Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
P-14 Involvement of C-type Lectin Receptors in Neutrophil-Mediated Host Defense against Pulmonary Streptococcus pneumoniae Infection
- Keiko Ishii
- Department of Medical Microbiology, Mycology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
P-15 Pneumococcal surface protein A and glycolipid vaccine augments generation of long-lived plasma cells that produce antigen-specific IgG
- Koji Hayashizaki
- Department of Bacteriology, The Jikei University School of Medicine, Tokyo, Japan
P-16 The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Invasive Disease
- Masamitsu Kono
- Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
P-17 Effects of specific surface protein antigen, PspK, of non-encapsulated streptococcus pneumoniae on nasal carriage, shedding, and transmission among littermates of infant mice
- Muneki Hotomi
- Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
P-18 Investigation on the virulence of non-encapsulated Streptococcus pneumoniae using liquid agar pneumonia model
- Muneki Hotomi
- Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
P-19 Genetic linkage analysis identifies pneumococcal susceptibility locus in mice
- Ryodai Shindo
- Department of Microbiology and Infectious Disease, Toho University School of Medicine, Tokyo, Japan
Poster Viewing and Discussion 14:41-15:00
Session 4: Basic research-2 15:00-15:35
- Chair:
- Masaya YamaguchiOsaka University Graduate School of Dentistry, Japan
P-20 Bacteriological and molecular biological characterization of serotype 24F ST162 Streptococcus pneumoniae dependent on CO2 and temperature in Japanese children
- Jun Kobayashi
- Department of Laboratory Medicine, Nagano Children's Hospital, Nagano, Japan
P-21 Unbiased homeologous recombination during pneumococcal transformation allows for multiple chromosomal integration events
- Jun Kurushima
- Department of Bacteriology, School of Medicine, Gunma University, Gunma, Japan
P-22 Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection
- Hiroyuki Honda
- Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Japan
P-23 Clonality Analysis of Streptococcus pneumoniae in Clinical Specimens
- Delly C. Lestari
- Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
P-24 Bacterial transcytosis of Streptococcus pneumoniae across the host cells: An in vitro model for analysis of invasive potential
- Jun-ichi Kanatani
- Department of Bacteriology, Toyama Institute of Health, Toyama, Japan
P-25 Nasal epithelial barrier dysfunction involved in non-hematogenous pneumococcal dissemination to brain tissue
- Yuki Takahara
- Department of Oral Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan
Poster Viewing and Discussion 15:35-16:00
APS Plenary Lecture116:00-16:50
- Chair:
- Yuki Kinjo The Jikei University School of Medicine, Japan
PL1-1Nasal delivery of a universal protein antigen identified by CRISPRi-seq induces broad protection from pneumococcal superinfection
- Jan-Willem Veening
- University of Lausanne, Switzerland
Poster Award Ceremony16:50-17:00
Evening Symposium:
PPSV23 for Adults in Asia17:10-18:40
Co-sponsored by MSD K.K.
- Chair:
- Kazunori Oishi Toyama Institute of Health, Japan
ESY1-1Pneumococcal polysaccharide vaccine (PPSV23) for older adults in Japan
- Hideaki Nagai
- National Hospital Organization Tokyo Hospital, Japan
ESY1-2Current status and needs for pneumococcal polysaccharide vaccine (PPSV23) in older adults of South Korea
- Joon Young Song
- Korea University College of Medicine, South Korea
ESY1-3Surveillance of Invasive Pneumococcal Disease in Taiwan
- Cheng-Hsun Chiu
- Chang Gung Memorial Hospital, Taiwan
Day 2: Friday, December 03, 2021
APS Plenary Lecture 209:00-10:00
- Chair:
- Kazunori Oishi Toyama Institute of Health, Japan
PL2-1Pneumococcal-Host Interactions Affecting Carriage and Transmission
- Jeffrey N. Weiser
- New York University, USA
Session 5:
Epidemiology 1 10:00-10:50
- Chair:
- Naruhiko Ishiwada Chiba University, Japan
SE5-1Global impact of PCV10/13 on invasive pneumococcal disease serotype distribution and incidence rates among children and adults: results from the PSERENADE project
- Julia C. Bennet and Maria Garcia Quesada
- Johns Hopkins Bloomberg School of Public Health, USA
SE5-2Dynamic changes in serotype distribution of invasive pneumococcal disease among adults after introduction of pediatric pneumococcal conjugate vaccine (PCV) in 2013–2019 in Japan
- Kazunori Oishi
- Toyama Institute of Health, Japan
Session 6 :
Epidemiology 2 11:00-11:50
- Chair:
- Kazuyoshi KawakamiTohoku University, Japan
SE6-1Molecular epidemiology of pneumococcal isolates in Japan
- Satoshi Nakano
- National Institute of Infectious Diseases, Japan
SE6-2Changes in molecular epidemiology in Korea after the introduction of Extended valency PCVs in Korean children
- Hyunju Lee
- Seoul National University Bundang Hospital, South Korea
Luncheon Seminar 2 :
Co-sponsored by SHIONOGI & CO., LTD. 12:00-13:00
- Chair:
- Hiroshi YotsuyanagiThe University of Tokyo, Japan
LS2-1Lessons learned from Pandemic: Similarity and difference in COVID-19 and Influenza
- Kazuhiro Tateda
- Toho University of Medicine, Japan
Session 7 :
Nasopharyngeal Carriage 13:10-14:00
- Chair:
- Shigeto HamaguchiOsaka University, Japan
SE7-1The low carriage prevalence of pneumococcus among community-dwelling older people
- Konosuke Morimoto
- Nagasaki University, Japan
SE7-2Using community vaccine type pneumococcal carriage to evaluate of reduced dosing PCV schedules in Vietnam
- Lay-Myint Yoshida
- Nagasaki University, Japan
Session 8 :
Sequential Administration of PCV13-PPSV23 14:00-14:40
- Chair:
- Satoshi IwataNational Cancer Center Hospital, Japan
SE8-1The immunogenicity of sequential administration of PCV13/ PPSV23 in pneumococcal vaccine-naïve adults ≥ 65 years of age
- Momoyo Azuma
- Tokushima University Hospital, Japan
SE8-2Pneumococcal vaccination in adult allogeneic hematopoietic stem cell transplant recipients
- Keiji Okinaka
- National Cancer Center Hospital, Japan
SSession 9 :
Novel Vaccines 14:50-16:10
- Chairs:
- Muneki Hotomi Wakayama Medical University, Japan
Yukihiro Akeda National Institute of Infectious Diseases, Japan
SE9-1Delivery of Streptococcus pneumoniae capsular polysaccharides by recombinant attenuated Salmonella vaccines
- Qingke Kong
- South Western University, China
SE9-2Broad-spectrum vaccine candidate using bivalent recombinant fusion proteins of Pneumococcal Surface Protein A (PspA) against Streptococcus pneumoniae
- Hiroki Nakayama
- The Research Foundation for Microbial Diseases of Osaka University, Japan
SE9-3Phase 3 trial to evaluate safety, tolerability and immunogenicity of V114 followed by 23-valent pneumococcal polysaccharide vaccine 6 months later in at-risk adults aged 18–49 years (PNEU-DAY)
- Luwy Musey
- Merck & Co., Inc., USA
SE9-4 Pivotal Study of the Safety, Tolerability and Immunogenicity of PCV20 in Adults
- Wendy Watson
- Pfizer, Inc,, USA
Joint Session:
Future outlooks of prevention of respiratory infectious diseases: New modalities and scheme16:30-18:00
Co-Sponsored by the 25th JSV & Sanofi K.K.
- Chairs:
- Ken J. IshiiDivision of Vaccine Science, Department of Microbiology, and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
- Kazunori OishiToyama Institute of Health, Japan
JSE-1Future Perspectives of Research and Development in Infectious Disease Prevention and Future Expectations of Clinical Applications
- Norio Ohmagari
- National Center for Global Health and Medicine, Japan
JSE-2Past, now and future of monoclonal antibodies: From treatment to prevention in infectious disease
- Susanna Esposito
- Pediatrics at the Faculty of Medicine and Surgery of the University of Parma, Italy